We are recruiting an outstanding candidate to participate in a project funded by international and national institutions. Funding is already available for one year (initial gross salary range 24,000-27,000€ depending on experience).
You will join our laboratory of Translational Research in Neuromuscular Diseases at the Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu in Barcelona.
Our Institute is a leading biomedical research hub in Europe for rare diseases and one of the largest pediatric Hospitals in the world. We are a multidisciplinary group recognized as a reference centre for neuromuscular diseases working with an extensive network of collaborators inside and outside Europe. We participate in several clinical trials for various neuromuscular and neurological conditions.
The main functions of the candidate will be to carry out experiments related to the project, in particular those related to cell cultures, protein co-immunoprecipitation, nucleic acid extraction techniques, PCR, etc. In addition, you will have the responsibility of managing the results and issuing reports on them. The candidate will attend periodic meetings of the group and the research unit, where the results will be communicated and discussed critically.
We are looking for a self-driven and committed Project Manager to join the Project Management Office (PMO) at Foundation Sant Joan de Déu to provide daily scientific, technical and managerial support to European projects of the Project Management Office portfolio.
The International Post-Award Unit runs a portfolio of more than 50 active European projects (mainly from European Commission- Horizon 2020 and Horizon Europe), 10 of which are coordinated by our institution. The International Post-Award Unit includes a Project Management Office (PMO) offering support to Principal Investigators from IRSJD and other researchers from Sant Joan de Déu ecosystem in project coordination. Our project manager’s team provides daily scientific, technical and managerial support to Principal Investigators to help them in successfully develop their international projects.
The candidate will be integrated in the PMO and shall be responsible for the effective implementation of the assigned projects ranging from Health to Social field. The person we are looking for must be proactive, responsible, flexible, empathic and service-oriented. He/she should be comfortable working on long-term strategic plans as well as day-to-day project management tasks.
We are looking for a talented and motivated pre-award manager specialized in proposal writing to join the International Pre-Award Unit at Fundació Sant Joan de Déu. This team provides full support to Principal Investigators of Sant Joan de Déu’s research and innovation ecosystems to secure European and International competitive funding through identification of project ideas, deep knowledge of the funding Ecosystem and preparation of project proposals.
The position
The candidate will be in charge of co-developing successful research and innovation proposals with the PIs, to be submitted to European Commission-funded programmes. The final objective of this position is to maximize the value of the projects submitted in terms of research outputs, outcomes and impact. This position focuses on primarily on European Commission calls, ranging from Horizon Europe, EU4Health Programme, Erasmus+, CERV, among others, but also including other European and International public and private sources of funding such as US-NIH or private foundations.
Main tasks and responsibilities
Buscamos un/a Research Coordinator altamente motivado/a para unirse a nuestro equipo en el área de Cirugía Ortopédica y Traumatología pediátrica. El candidato/a seleccionado/a proporcionará apoyo esencial en la ejecución y coordinación de estudios clínicos y proyectos de investigación. Esta es una excelente oportunidad para aquellos/as interesados/as en contribuir a la generación de conocimiento científico, con opciones de formación continua y la posibilidad de realizar un doctorado.
Las principales funciones de la posicón serán:
• Coordinar y gestionar proyectos de investigación clínica desde la fase de planificación hasta la finalización.
• Recopilar, organizar y gestionar datos clínicos en bases de datos online (e.g. REDCap).
• Realizar análisis estadísticos preliminares y apoyar en la elaboración de informes científicos.
• Reclutar pacientes/participantes para los estudios y mantener su seguimiento.
• Asegurar el cumplimiento de los protocolos de investigación y normativas éticas/regulatorias vigentes.
• Colaborar con equipos multidisciplinarios y facilitar la comunicación entre los investigadores.
• Participar en la redacción de publicaciones científicas y presentaciones.
• Apoyar en la búsqueda de financiación a través de becas competitivas.
Drug resistance is one of the major challenges in paediatric cancer. Treating paediatric high-risk neuroblastoma, which is the most common extracranial solid tumour in children under one-year-old, is difficult as it frequently develops therapy resistance, leading to treatment failure, tumour relapse, and higher mortality rates. Unfortunately, there are currently limited therapeutic options available for resistant high-risk neuroblastoma. Therefore, there is a need to develop more targeted treatment strategies to overcome therapy resistance. The process of therapy resistance is not entirely understood, but it is believed to be driven by multiple molecular mechanisms, including genetic alterations and epigenetic changes.
We are seeking a highly motivated and talented pre-doctoral candidate to develop a thesis project in the field of molecular biology of neuroblastoma. The candidate will be part of a research project that has received competitive funding from the Instituto de Salud Carlos III. The project aims to investigate the molecular mechanisms underlying therapy resistance to develop more effective treatment strategies and improve outcomes for neuroblastoma patients. The project includes using a range of molecular biology techniques and muti-omic approaches, including cell cultures and cell lines, animal models, and tissue samples from neuroblastoma patients.
The successful candidate will be responsible for tasks intrinsic to a Ph.D. thesis, including literature review and critical analysis, hypothesis formulation, experimental design and implementation, data analysis, interpretation, and manuscript preparation for publication in peer-reviewed journals.
The experiments will encompass functional in vitro studies in cultured cells, molecular techniques such as real-time qPCR, immunoblot, and immunofluorescence, as well as in vivo studies using rodent models to evaluate the effectiveness of new treatments.
Additionally, the candidate will use patient tissue samples to validate the research findings.
Throughout the thesis development, the candidate will also employ various multi-omic approaches to comprehensively characterize molecular alterations in drug-resistant patients. Furthermore, the candidate will collaborate closely with an interdisciplinary team of clinicians and researchers.
Other tasks:
• Biological sample extraction, collection and processing.
• Participation in the animal experimentation procedures.
• Contribution to the publication of research results in national and international journals.
• Presentation of research results at national and international conferences.
• Data analysis and visualization.
• Comply with the 4Rs (reduction, reuse, recycling and recovery) and ethics involving patient samples and animals in research.
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